A canine carrier of the MDR1 gene is approximately 200 times more sensitive to the same medicine dose given to a non-carrier dog, which is why testing is so important. Depending on the results, a trusted vet can recommend an alternative medication course that isn't harmful to dogs Carrier: Both the normal and mutant copies of the gene detected. Dog is a carrier for the MDR1 mutation, and can pass on a copy of the defective gene to its offspring 50% 0f the time. n/n: Clear: Dog tested negative for the MDR gene mutation, and will not pass on the defective gene to its offspring Drugs that are known to be transported by the human or rodent forms of the protein encoded by the MDR1 gene but appear to be tolerated by dogs with the MDR1 mutation:. Morphine, buprenorphine, fentanyl (opioid analgesics or pain medications)- We suspect that these drugs are pumped by P-glycoprotein (the protein encoded by the MDR1 gene) in dogs because they have been reported to be pumped by P. The phrase 'multidrug resistance mutation 1 (MDR1)' refers to a specific mutation that can occur at a gene known as the MDR1 gene, also known as the ABCB1 gene. Many herding breeds (most commonly Collies and Australian Shepherds) have a mutation at the MDR1 gene that makes them more sensitive to the negative effects of certain medications
Similarly, the MDR1 mutation is a dominant genetic trait, so the use of the word carrier for heterozygous dogs is incorrect. Both heterozygous and homozygous dogs can show drug toxicosis when given P-glycoprotein substrates MDR1 Breeding Guidelines. This chart provides guidelines for consideration when owners are contemplating breeding dogs that may be affected by the MDR1 mutation. While it is ideal to use only Normal/Normal breeding pairs, one must always consider other genetic factors in addition to the MDR1 gene. Because the MDR1 gene is present in such a. MDR1 is a drug sensitivity that affects the majority - approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. (There are 13 other at-risk breeds including Border Collies, Australian Shepherds, German Shepherds, Shetland Sheepdogs, and Old English Sheepdogs, plus herding breed mixes. Common Symptoms. Multidrug resistance 1, also called MDR1, is an inherited condition affecting several breeds of dogs, especially herding dogs such as the German shepherd dog. The Mutation in the ABCB1 gene associated with MDR1 causes dysfunction of P-glycoprotein, which is responsible for removing certain drugs and toxins from the body
A (CLEAR/NORMAL): These dogs have two copies of the normal gene and will neither develop MDR1 nor pass this mutation to their offspring.. B (CARRIER/AFFECTED): These dogs have one copy of the normal gene and one copy of the mutation associated with this disease.They can react to certain drugs at higher doses and pass the mutation to 50% of its offspring, on average Carrier - Genotype: N / MDR1 [ Heterozygous ] The dog carries one copy of the mutant gene and one copy of the normal gene. The dog may develop MDR1 Gene Defect / Ivermectin Sensitivity. Since it carries the mutant gene, it can pass it on to its offspring with the probability of 50%.. MDR1 & DM. Degenerative Myelopathy is a debilitating disease that causes gradual paralysis in many dog breeds. It is caused by a degeneration of the spinal cord that onsets typically between 8 and 14 years of age. It presents first with the loss of coordination of the hind legs. It will typically worsen over six months to a year, resulting in.
(The MDR1 means Multi-Drug Resistant gene) Ivermectin (antiparasitic agent) Heartguard Loperamide (Imodium: over-the-counter antidiarrheal agent) Carrier (A/N) This dog is heterozygous A/N, with one mutated copy of the gene and one normal copy of the gene, and is classified as a carrier. Carriers are far less likely to develop DM, but we. Both the normal and mutant copies of the gene detected. Some sensitivity to listed drugs can occur. Dog is a carrier for the MDR1 mutation, and can pass on a copy of the defective gene to its offspring 50% 0f the time. n/n: Clear: Dog tested negative for the MDR gene mutation, and will not pass on the defective gene to its offspring Dog is a carrier for the MDR1 mutation, and can pass on a copy of the defective gene to its offspring 50% 0f the time. The dog carries two copies of the mutant gene and is homozygous for the MDR1 mutation. The dog will react to Ivermectin, or other listed drugs, and will always pass a copy of the mutated gene to its offspring..
The same problem caused by the MDR1 mutation can be triggered by several medications. The effect of the drugs may result in the same toxicity in healthy dogs as would occur with dogs who have tested positive for the MDR1 mutation. Of course, these drugs would affect dogs that have been cleared, those that are carriers, and those that are affected MDR1 is an inherited condition that makes affected dogs particularly sensitive to drugs like ivermectin (anti-parasitic) and loperamide (opioid to treat diarrhoea). In normal dogs the blood/brain barrier protects the brain cells from various drugs and toxins. P-glycoprotein is a protein which physically pumps drugs and toxins from the. MDR1 Carrier/not affected. $1,500. Reserved. See more. Expectations for this litter . Coats. We expect a colorful litter due to Colbie's merle gene and Newt's white factoring. Possibilities include sable/white, sable merle, tri-colored, and blue merle. We do not expect any bi-colors in this litter. We expect them all to have moderately long. Multi CHAMPION Multi BOB. CKC GRAND CHAMPION & UKC CH . Follow Me Red Velvet CGN Velvet (Mya & Rival) 15.5 PRA, HC, DM, CEA CLEAR. MDR1 Carrier. Ophthalmologist Eye Exam: Norma Multidrug Resistance Gene (MDR1) Test. A number of dog breeds are more prone to have serious side effects from certain drugs than other breeds. The cause of this sensitivity is a DNA sequence change (mutation) in the dog's multi-drug resistance gene, known as the MDR1 gene. The function of this gene is to prevent dangerous drugs from entering.
. Conversely, increased MDR1 (resulting in increased cellular P-glycoprotein drug pumps) in tumor cells can induce resistance to chemotherapy. As noted the gene name MDR1 derives from multi-drug resistance dogs which are carriers for the MDR1 mutation and by 30-50% in dogs which are positive for the MDR1 mutation. Is it inherited? The inability to produce the PgP protein is a genetic mutation, and therefore it is an inherited characteristic. The gene responsible is what is known as an autosomal recessive - that mean
MDR1 Multi Drug Resistance. The easy explanation is that MDR1 is what is causing Collie and Sheltie to die when treated with Ivomec. That much is known by most dog fanciers. But that is only a small part of the truth. Some dog breeds are more sensitive to certain drugs compared to other breeds. For example, Australian Shepherds, Collies. Introduction. P-glycoprotein is an adenosine triphosphate (ATP)-driven drug efflux carrier, encoded by the multidrug resistance gene MDR1, also referred to as ABCB1.P-glycoprotein transports a broad variety of structurally diverse compounds that are usually hydrophilic and amphiphatic (Fromm, 2004), including many drugs commonly used in veterinary medicine (Mealey, 2004) MDR1 is the abbreviated name of a gene called Multi-Drug Resistance 1. A mutation of this gene causes sensitivity to Ivermectin and a number of other drugs. Dogs having two copies of the mutation will lead to drug reactions, but having a single copy can also confer some sensitivity with some drugs Ivermectin sensitivity or MDR1 gene defect is a hereditary health condition that is passed from parent dogs to their offspring by means of autosomal recessive heredity. This means that as well as being able to find out the status of an individual dog by DNA testing for Ivermectin sensitivity in the Border collie, by testing both parent dogs.
MDR1- clear, PRA-PRCD- clear, DM- clear, CEA- clear, HU- clear. Chicory is OFA certified hips clear, elbows clear. Thyroid normal. MDR1- carrier, PRA-PRCD- clear, DM- clear, CEA- clear, HU- clear.. Hip Prelims Good. Elbows Normal. Eye CERT Normal. Thyroid Normal. Degenerative Myelopathy, (DM) Clear. Exercise-Induced Collapse, (EIC) Clear. Cerebellar Ataxia Clear. Multi-Drug Resistance 1, (MDR1) Carrier. Primary Ciliary Dyskinesia, (PCD) Clear
Jack NW Aloha Jack Rabbit BEST BRED-BY EXHIBITOR IN SHOW at the 2019 MASCUSA Nationals Height: 16.5 tall. PRA: Clear . HC: Clear . MDR1: Clea My MDR1 dog had paralysis from Frontline by: Wendy I thought Frontline was wonderful until my dog at age 8 months had a paralysis of her hind leg from it. Just a note, if you use flea preventatives consider that they are effective against fleas for 90 days yet tell you to reapply every 30 days MDR1 - German Shepherd Pituitary Dwarfism. The incidence of the MDR1 gene for the breeds affected are for example: Rough Collies 70%, Australian Shepherds 50%, Shetland Sheepdogs 15%, German Shepherds 15% and Border Collies < 5%. The list has many more breeds contained within it but mostly they are in the pastoral group The multidrug carrier P-glycoprotein (P-gp), encoded by the MDR1 (ABCB1) gene, belongs to the family of membrane bound ATP-binding cassette (ABC) transporters . P-glycoprotein is an ATP-driven efflux pump that confers multidrug resistance (MDR) to cancer cells by actively extruding a wide range of structurally unrelated chemotherapeutic. Hurricane is a bundle of sweet energy, and very lovable. Promise is a sweet girl with the biggest heart. The combination is win/win. The puppies will be excellent in temperament, and genetics clear non-carrier of CEA, PRA, CN, HUU, VWDII, DM, and MDR1
Mom being clear and Dad MDR1 Carrier/1 copy. We have tested Paisley she is also a MDR1 carrier/1 copy. Cleared through parentage on others testing. PAISLEY RED NOTE RYTHM. CV'S RYTHMN N BLUES. CALLIE. Callie is the daughter of Paisley and sister to Bindi. Callie is a very sweet and playful girl who LOVES the kids The MDR1 gene codes for P-glycoprotein, a cellular pump responsible for the transport of certain chemicals. Mutations in this gene cause faults or delays in the removal of some drugs from cells. This is most evident in the brain. Dogs with the MDR1 mutation are at risk of serious drug toxicities at doses that are safe to other dogs Carrier for MDR1 DD Aussies Ko-Jak (son of Austin/Cooper) KoJak is a Black Tri BET that is full of love & life. He has lots of bone even tho he is little as well as deep copper with a fabulous personality, Jak is out of Austin & by Cooper. He stands at 11.5 and weighs 12.5 pounds. We are so happy with all the colors he is producing
Carrier PRA-PRCD- MDR1- HUU . Rikashay's Worth The Risk Risky AKC Miniature American Shepherd 16 Tall, 25 lbs. Sire:Sire: Dixie's Will I Am. Dam: Rikashay's Causin Riot. Neg CD,CD1-DM-HC-MDR1 Carrier PRA-PRCD . Rikashay's Bam-Ba-Lam Black Betty Betty AKC Miniature American Shepherd. PAW PRINTS GENETIC HEALTH TESTS cea-clear, dm-clear, hc-carrier, mdr1-carrier, praprcd-clear Dob 11-12-2014 15 sml Mini Fem.
MDR1 - Carrier. Broadway's Brooklyn's Here aka Conlon - SOLD (Now known as Hermes, living as a water hound with his new family in Michigan) Male; Extreme White with Gold Spotting MDR1 - Carrier. Broadway's My Lovey-Dovey Baby aka Medda - SOLD (now known as Jersey Girl, living locally with her half sister (MDR1 carrier) Pepsi CRUZ- 15 Blue Merle STUD Pepsi. Pepsi is a spunky, fun-loving girl who loves her family! (PRCA Carrier) Mae Shiner - Blue eyed tri STUD Pepsi. Red Tri female with blue eyes and ticking (freckles) (MDR1 Carrier) Squeaky Beak Shiner - Blue eyed tri STU
MDR1 - Clear A DM - Carrier. OFA - Good. Sires. Cedar Valley's Touch of Heaven Ciel. Here you can view our available Sires. Genetic Testing. H.C. - Clear A PRA-PRCD - Clear A CEA - Clear A MDR1 - Clear A. The MDR1 gene variant can be detected, using molecular genetic testing techniques. By DNA testing the mutation can be shown directly. The testing is carried out by state of the art laboratory methods and therefore provides a very high accuracy. In general DNA tests can be done at any age. These tests identify both affected and carrier animals MDR1: Carrier. CEA: Normal (clear) CD: Normal (clear) OFA: Prelim Good (10/2/17) Cedar Crest Italian Dream. aka Gino. AKC Australian Shepherd. son of Dixie and Turbo. 7-20-2018. 18 and 45 pounds. clear by parentage of all genetic markers. Timberline Perfect Storm @ Cedarcrest. AKA Turbo. AKC Australian Shepherd. 18 50 pounds. July 19, 2017
A frequent polymorphism of phase 4 MDR1 carrier occurring in about 12% of patients is the homozygous C3435T exchange. In these patients, (i) less than half of the normal MDR1 gene expression in the intestine, (ii) much lower gene induction by rifampin, and (iii) decreased excretion of digoxin into the gut was reported Cholesterol-Containing Nuclease-Resistant siRNA Accumulates in Tumors in a Carrier-free Mode and Silences MDR1 Gene Mol Ther Nucleic Acids. 2017 Mar 17;6:209-220. doi: 10.1016/j.omtn.2016.12.011. Epub 2017 Jan 3. Authors Ivan V Chernikov 1. Paw Prints Genetics- MDR1 Carrier B Locus- B/b (Red Factored) CAER (OFA Eyes)- NORMAL/CLEAR OFA Hips- FAIR OFA Elbows- NORMAL CHIC# 158959. Good To Go Gogo AKC Registered Black Tri w/ Marbled Eyes Paw Prints Genetics- DM & MDR1 carrier B Locus B/b- Red Factored CAER (OFA Eyes)-NORMAL/CLEAR OFA Hips-FAIR OFA Elbows- NORMAL
Autumn ages 8 1/2 months. Early days yet with growing out Autumn , hoping she lives up to her potential . Autumn is CEA unaffected. Coloboma Free. DNA results . Genetically Clear for CEA Ch and VW3 . Carrier for MDR1 and DM. Photos at 9, 14 and 18 weeks. Pedigree for Limbunya Autumn Glow *Freestyles Out of the Blue* ASCA/AKC. RF Blue Merle Female. DOB: 11/30/2020. Clear through parentage for DM, CD, CR, PRAD/PRA, CMCD, HC, MDR1. Tested for CEA- Results- Carrier/not affecte MDR1 Carrier. DM Carrier . Anya of Wynter Spirit Shepherds. HD A ED O. MDR1 Clear . DM Clear . DNA Profile through Embark. FCI Registered. Wyntershepherds@gmail.com. 804-439-0293. Thank you for visiting us here at Wynter Spirit Shepherds The Interceptor Shortage - Today Nancy Kelso, D.V.M Interceptor seems to have disappeared from the market completely. Sentinel (Interceptor and Program, a flea growth regulator) is now available. The main ingredient in Interceptor (milbemycin) is also available in Comboguard and Trifexis, with a flea prevention product, too, but no one is currently manufacturing milbemycin alone. 2019 Season Best - 15'2. AKC Fast CAT. 2019 Season Best - 27.33 MPH. 2019 Season Point Total - 96.92. Achievements. Multiple AKC Rally First Place. Genetic Health. MDR1 Carrier. Panel Results in Link
ASCA & AKC Reg. About 19 And 35 pounds. Blue Merle with one Blue eye and one Brown eye. Health Testing Clear for CEA, CD, DM, HC, HUU, MFR1, NCL6, PRCD, and MDR1 Carrier Dna HSF4: Clear. Dna MDR1: PEDIGREE. MASON. Seventy Seven Champion Of Blow Kisses. Mason - maschio australian shepherd. Mason - maschio australian shepherd. Mason - maschio australian shepherd. 1 - 3 OUR Females. Elbows Normal. CMR1 clear , NCL6 clear , MDR1 carrier , ICM (AS) clear , VWB I clear, VWB III clear, CMO clear, NCL 8 clear, IVDD clear, CFVII clear, ICM (BC) clear, E-IC clear, CDPA clear. Owned by Dan Parsons. Parsons Bright Lady Lila. Onthehills Bright Eyed Diego X Parsons Lady BriAnna. Red Tri 48# MDR1 - CLEAR/CARRIER. DMS - aabbCC (Low Risk) aabb002.01/002.01. Merle tested - m/Ma (Atypical Merle) ONLY AVAILABLE AT STUD TO APPROVED DNA TESTED BITCHES. (proven Stud - 5 matings, 5 litters to date) Puppies from Litters to date have produced 2 x Res CC winners from 3 puppies shown. both from Puppy Classes MDR1: carrier. Due femmine (red merle e red tricolor) e un maschio (red merle). See More. Azienda Agricola Myosotis. November 28, 2017 Â· Cuccioli stupendi!
Parsons Always Helping A FIN (friend in need) Onthehills Bright Eyed Diego X (Parsons) Country Time Cloe. Black Tri male 59#. Pawprint genetic tested full Panel DM and MDR1 carrier clear of everthing else. Located in Novelty, Ohio. Owned by Michelle Wiece . In everyday life he is real clown who loves new challenges, environmentalism and social. HD A DNA tester: CLEAR TNS, IGS, MDR1, carrier CEA Litter's Hd index: 102 Lifelong support, as well as breeders with humor are promised. PM or call 73 070-441 1
. The entire litter will be CEA Carrier, as the Sire is CEA Affected and the Dam is CEA Clear. Dam: Kristull Encore Encore Please click on her picture for her personal page . Sire: Ricmar's Kristull Tradition Tob CEA Normal Eyed Noncarrier /PRA non carrier ~ Mdr1 N/N. Photo property of Adair Springs Collies. Past Sires. CH Adair Wizard Ohm Jazz of Turnberry Jazz CH Sassy's Feel Like A Rock Star X CH Turnberry Signature Move. Mdr1 N/N ~ CERF CH. Jazz finished with 2 back to back majors at 13 months old Clear MDR1/PRA/HC/CEA/HU Carrier ( not affected) OFA hips/patellas/elbows preliminary clear/too young for certification. OFA Eye/CERF clear at 8 weeks. AP Ranch Meet Me in Montana (Monte). If one is a carrier, then as you say unless the puppies were all DM tested clear themselves, the breeder should not make the statement that they are clear. As you say, if one parent is a carrier, some of the puppies may also be carriers. The wording may be the problem - breeder meaning the puppies are not going to be rated affected with two.
The MDR1 TTT haplotype carriers needed more fentanyl compared with the CGC haplotype carriers during the first 48 hours after surgery (). Nausea, vomiting, and dizziness were not found to have significant differences among the above three SNPs and their haplotypes () CLEAR EXCEPT MDR1: NORMAL/CARRIER (DAM TO SEVERAL OF OUR YOUNG MINI AUSSIES!!) MOON HAS BEEN RETIRED AND ADOPTED TO A FOREVER PET HOME!! PASKERO'S TUX-NSDR & MASCA CHAPMAN'S TUX-ASDR NSDR, ASDR & MASCA Registered BLACK TRI BET (one blue eye, one brown eye) 3/4 Collar Stands 14 1/2 Tall, 20 lbs., Red factored Proven BET producer & MULTIPLE CH. Genetic Testing via parentage - Dam - Carrier for MDR1 / Sire - Carrier for MDR1 & DM. The Cheerful Summer Litter. Mosaic's Puppies. YOGI & WILDFIRE LITTER COMING SOON MID TO LATE JULY. Estimated size to be between 17 to 18 tall weighing 30# to 40# Puppies to be clear through parents on all genetic testing except MDR1 & PRCD
The MDR1 gene (Multi-Drug Resistance Gene) (ABCB1) encodes P-glycoprotein, a drug transporter that plays a key role in drug disposition. P-glycoprotein is a very important component of hematoencephalic barrier (blood-brain barrier) that prevents entry of many potentially toxic compounds into the CNS (central nervous system).. Hadley-13 red blue eyed tri female stunning mdr1 carrier only. Tails- 10 black tri toy clear for all but mdr1. Mouse-11 blue merle Cea Carrier MDR1 (Affected) Fallon- 12 blue merle female full panel clear (jelena sister) Kiera-12 red blue eyed bi female (Daughter of Semper) Kal-Elle- Blue eyed tri large toy panel clear for all but mdr1
CEA Carrier & MDR1 CLEAR Keelin Double M is a gorgeous blond boy that we got out of California from Ian Wilson and Adrianne Marcus of Double M kennels. Out of our male Tocho and their girl Misty, we feel we got the best of both bloodlines in Keelin Sensitivity of Collies to certain pharmaceuticals, in particular for treatment of heartworm and mites (ivermectin), is now known to be caused by a genetic defect in the mechanism that prevents drugs from building up in the brain. This mutation is recessive and is called mdr1-1Î”. The normal gene that protects the brain is called MDR1
Chance is a carrier for CEA, and a non carrier for PRA, DM, CN, HUU, & MDR1. Lassie (Dam) Chance (Sire) Chance (Sire) Lassie is a golden sable. She is a non-carrier for CEA, PRA, DM, CN, HUU, & carrier for MDR1. Lassie Pups, born 5/22/2021. Chance X Crawley Pups! Chance (Sire) Chance (Sire) Chance (Sire) Chance, our stud, is a Tri-Factored. Heartworm preventive is safe: The medications used in monthly heartworm preventives are at levels safe enough even for dogs with the MDR1 mutation, as long as the preventives are given according to the manufacturers' recommended dose. Horse owners, beware: If your canine assistant laps up some of your horse's paste dewormer or eats the manure. P-glycoprotein (P-gp) or multidrug resistance protein 1 (Mdr1) is a member of the ATP binding cassette (ABC) superfamily of transmembrane transport proteins and in the dog is encoded by the gene Mdr1. P-gp is an important drug efflux transporter that has a significant impact on the gastrointestinal absorption, distribution, metabolism. Dash - Dash is a white factored blue merle rough coat collie. He is a non carrier for CEA and MDR1, He is N/M for DM. Dash is a sweet tender hearted fellow. Our Retired Boys - Chance, Ice, Daren and Huey. You can see additional pictures of our dogs on our Facebook page Cartercollies by clicking the link at the end of this page
.5 inches BET carrier ASDR/ASA. PEDIGREE. Meet our new girl !! Harley Triple S Gritty as a Blue Harley AKC registration pending. PEDIGRE MDR1: Normal/Carrier. Multifocal Retinopathy 1: Normal. Neuronal Ceroid Lipofuscinosis 6: Normal . PRA/PRCD: Normal. Herding Instinct: Low. Sire: CH. Sentikki I Allready Know Dam: CH. Seventy Seven Mon Cheri COPPER SKY LIPSTICK N' WHISKE Heritable MDR1 gene mutations can affect any dog or cat breed and breed crosses and mixed breeds , but are most commonly found in dog breeds of herding breed ancestry such as the Collie, Long-haired Whippet, Australian Shepherd, Miniature Australian Shepherd, McNab Shepherd, and Silken Windhound. In fact, up to 70% of Collies have the mutated. Full Panel: Clear, except MDR1 carrier Hips: OFA Prelim: fair Elbows/Patellas: normal. GCH CH Moonbaby's Starstruck Independence Of Away To Me (Indy) Miniature American Shepherd Sire: Legacy's American Outlaw Dam: Moonbaby's All American Girl DOB: 9/27/2015 Height: 16 3/4 inches Eye Cerf: normal Prcd/Pra: clea
MDR1-clear, DM-n/n, CEA-n/n, CD- n/n, CMR1- n/n, DM- n/n, D-Locus D/D Hips-good, Elbows-good, Eyes-normal. Aspen AKC Irongate's Angel of Zion: She is our big ole' baby. She is our biggest girl about 20in tall and about 55 pounds. She is a guard dog and does great with guarding the perimeter and making sure that her humans are always. resulted affected with the MDR1 âˆ’/âˆ’ genotype. A high number of BoC dogs was tested in Italy (208) and the MDR1 mutant allele frequency was 4 per cent, with 93 per cent of homozygous clear animals and only 7 per cent of carriers. No genetic affected dogs were observed (with âˆ’/âˆ’ genotype). Going on with collie-related breeds, tested BeC had
The MDR1 gene encodes for p-glycoprotein which is an important component of certain cell membranes and which acts as a pump to help clear possible toxins from the cells. P-glycoprotein plays a particularly important role in the cells of the blood-brain barrier where it helps to keep drugs and other chemicals from entering the brain MDR1 +/- (Carrier), CEA Clear REPEAT MATING THAT PRODUCED SHANDLMAIN BLU GENES (pictured below) 2 Tri colour male, 2 Tri colour Female, 1 Blue Merle Male, 2 Blue Merle Female. We are retaining possibly 2 puppies from this litter, remaining puppies are available to permanent loving show or pet homes. Enquiries welcome Mdr1 gene expression in childhood acute lymphoblastic leukemias and lymphomas: a critical evaluation by four techniques. Brophy NA(1), Marie JP, Rojas VA, Warnke RA, McFall PJ, Smith SD, Sikic BI. Author information: (1)Department of Medicine Oncology, Stanford University School of Medicine, CA Dixie (aka Hot Tamale) is a tri factored, sable merle female with Van-M lines! She is a non carrier for CEA, PRA, CN, & HUU. She is a carrier only for DM and MDR1. This stunning girl should have sables, tri colors, sable merles, and blue merles with Chance Quantitative real-time PCR analysis of Mrp1, Mrp2, Mrp3, Mrp4, Bcrp, Mdr1a, and Mdr1b expression in the brain of wild-type mice, mdr1 âˆ’/âˆ’ knockout mice, and bcrp âˆ’/âˆ’ knockout mice. The data was calculated from triplicate carrier mRNA determinations from brain tissues of three animals per group and represents means Â± SD
Bonnie is a normal eyed/non carrier rough collie. DNA tested clear for CEA, rcd2/PRA, DM, CN, HUU, and MDR1 N/N. Her testing for DMS was just completed and is the best possible outcome so Miss Bonnie is perfect fergus glenelg's shadows of the wood cea clear; mdr1 clear; dm clear; pra clear; dms pendin Breed: Collie. DOB: 03/22/2021 ( 15 weeks old) Sire: Twas A Telegram (DN57069201) Dam: Nightstar's Positively Entertaining (DN44546007) Males: 3. Females: 1. Health & Vaccines: Through parentage, pups are all CEA non-carriers and have at least one Normal gene for MDR1 and DM Health testing: Blue trophy panel tested; all clear, carrier MDR1 (not affected) Luna. Luna is super shy but the sweetest dog we've ever had! She settled in to life on the farm very well and is an excellent protector over the yard. She prefers to snuggle and follow me around rather than get rowdy with the other dogs. Her red merle coloring and.